Monday, October 11, 2010

Transamin 250mg - any side effect?

Transamin (Tranexamic Acid) is often prescribed for excessive bleeding. It is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin, a molecule responsible for the degradation of fibrin. Fibrin is the basic framework for the formation of a blood clot in hemostasis. It has roughly 8 times the antifibrinolytic activity of an older analogue, ε-aminoacaproic acid.

Therapeutic Uses of Transamin

a) Menstrual bleeding

b) Haemophilia

c) Angioedema

d) Cardiac surgery

Orthopedic Surgery

Transamin is used in orthopedic surgery to reduce bloodloss. It is of proven value in clearing the field of surgery and reducing per and postoperative blood loss. Drain and number of transfusion is reduced. However the hidden blood loss is not reduced. Still it is becoming an important tool in the anaesthetist’s arsenal. It is commonly used in joint replacement surgery.

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